Carl W, Emrich L S
Roswell Park Memorial Institute, School of Dental Medicine, Buffalo, N.Y.
J Prosthet Dent. 1991 Sep;66(3):361-9. doi: 10.1016/0022-3913(91)90264-w.
Oral mucositis is among the complications of head and neck irradiation and systemic chemotherapy. To determine whether or not mucositis could be prevented or reduced in intensity by using Kamillosan Liquidum as an oral rinse, 98 patients were placed on study protocols. Twenty patients who were treated with radiation therapy and 46 patients who received systemic chemotherapy participated in prophylactic oral care with Kamillosan oral rinse. Thirty-two patients were treated therapeutically after mucositis had developed. Sixteen patients receiving chemotherapy were treated therapeutically and prophylactically with Kamillosan oral rinse during repeated cycles of chemotherapy. Only one of the 20 patients who had had radiation therapy developed grade 3 mucositis in the final week of treatment. Thirty-six of the 46 patients undergoing chemotherapy did not develop clinically noticeable mucositis. It appears that resolution of mucositis is accelerated by Kamillosan rinse. Prophylactic oral care appeared to modify the oral environment favorably and maintain tissue integrity.
口腔黏膜炎是头颈部放疗和全身化疗的并发症之一。为了确定使用卡米洛森液漱口能否预防或减轻黏膜炎的严重程度，98名患者被纳入研究方案。20名接受放射治疗的患者和46名接受全身化疗的患者参与了使用卡米洛森漱口水的预防性口腔护理。32名患者在黏膜炎发生后接受了治疗。16名接受化疗的患者在重复化疗周期中同时接受了卡米洛森漱口水的治疗和预防性护理。20名接受放射治疗的患者中只有1人在治疗的最后一周出现了3级黏膜炎。46名接受化疗的患者中有36人没有出现临床上明显的黏膜炎。卡米洛森漱口水似乎能加速黏膜炎的消退。预防性口腔护理似乎能有利地改善口腔环境并维持组织完整性。
