源自环丙烷二羧酸的噻二唑和1,2,4-三唑的合成。
Synthesis of thiadiazoles and 1,2,4-triazoles derived from cyclopropane dicarboxylic acid.
作者信息
Sharba A Hussain K, Al-Bayati Rida H, Rezki Nadjet, Aouad Mohammed R
机构信息
Department of Chemistry, College of Science, Al-Mustansirya University, Baghdad, Iraq.
出版信息
Molecules. 2005 Sep 30;10(9):1153-60. doi: 10.3390/10091153.
New heterocyclic derivatives of cyclopropane dicarboxylic acid comprising thiadiazole and 1,2,4-triazole moieties are reported. Reaction of 1,1-cyclopropane dicarboxylic acid (1) with thiosemicarbazide and phosphorous oxychloride resulted in 1,1-bis (2-amino-1,3,4-thiadiazol-5- yl)cyclopropane (2). Cyclopropane dicarboxylic acid thiosemicarbazide (6) was converted into 1,1-bis(3-thio-4H-1,2,4-triazol-5-yl) cyclo- propane (7) by ring closure in an alkaline medium. The thiadiazole 2 and the triazole 7 were converted into a variety of derivatives.
报道了包含噻二唑和1,2,4 - 三唑部分的环丙烷二羧酸新杂环衍生物。1,1 - 环丙烷二羧酸（1）与氨基硫脲和三氯氧磷反应生成1,1 - 双（2 - 氨基 - 1,3,4 - 噻二唑 - 5 - 基）环丙烷（2）。环丙烷二羧酸氨基硫脲（6）在碱性介质中通过闭环反应转化为1,1 - 双（3 - 硫代 - 4H - 1,2,4 - 三唑 - 5 - 基）环丙烷（7）。噻二唑2和三唑7被转化为多种衍生物。
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