新型偶氮席夫碱的合成及其抗菌和抗真菌活性。
Synthesis of novel azo Schiff bases and their antibacterial and antifungal activities.
作者信息
Jarrahpour A A, Motamedifar M, Pakshir K, Hadi N, Zarei M
机构信息
Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran.
出版信息
Molecules. 2004 Sep 30;9(10):815-24. doi: 10.3390/91000815.
Abstract
Ten new azo Schiff bases 5a-h and 7a-b were prepared in excellent yields via the condensation of different aromatic amines and a new azoaldehyde, 2-hydroxy-3- methoxy-5-(4-methoxyphenylazo)benzaldehyde (4) by two different methods. All new compounds were tested against five microorganisms: Staphylococcus aureus (Gram positive and methicillin resistant), Bacillus subtilis (Gram positive), Kelebsiella pneumonia, Pseudomonas aeruginosa and Escherichia coli (all Gram negative). Compounds 4, 5a, 5c, 5d and 5g were moderately active against Staphylococcus aureus and Bacillus subtilis. Compound 7b was highly active against Bacillus subtilis and moderately active against Staphylococcus aureus. Other compounds were inactive against these strains of bacteria. The antifungal activities of these compounds were also tested against eight different fungal species. None of them were active against the fungi species tested.
摘要
通过两种不同方法，使不同的芳香胺与一种新型偶氮醛2-羟基-3-甲氧基-5-(4-甲氧基苯基偶氮)苯甲醛(4)缩合，以优异的产率制备了10种新型偶氮席夫碱5a - h和7a - b。所有新化合物均针对5种微生物进行了测试：金黄色葡萄球菌(革兰氏阳性且耐甲氧西林)、枯草芽孢杆菌(革兰氏阳性)、肺炎克雷伯菌、铜绿假单胞菌和大肠杆菌(均为革兰氏阴性)。化合物4、5a、5c、5d和5g对金黄色葡萄球菌和枯草芽孢杆菌具有中等活性。化合物7b对枯草芽孢杆菌具有高活性，对金黄色葡萄球菌具有中等活性。其他化合物对这些细菌菌株无活性。还针对8种不同的真菌物种测试了这些化合物的抗真菌活性。它们对所测试的真菌物种均无活性。
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