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2-硫代乙内酰脲对各种亲电试剂的反应活性：在新型2-亚烷基-3,5-二氢-4H-咪唑-4-酮合成中的应用

Reactivity of 2-thiohydantoins towards various electrophilic reagents: applications to the synthesis of new 2-ylidene-3,5-dihydro-4H-imidazol-4-ones.

作者信息

Chérouvrier Jean-René, Carreaux François, Bazureau Jean Pierre

机构信息

Université de Rennes 1, Institut de Chimie, Synthèse & Electrosynthèses Organiques 3, UMR 6510, Bât. 10A, Campus de Beaulieu, Avenue du Général Leclerc, CS 74205, 35042 RENNES Cedex, France.

出版信息

Molecules. 2004 Sep 30;9(10):867-75. doi: 10.3390/91000867.

DOI:10.3390/91000867
PMID:18007487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6147305/
Abstract

A new route to 5-(imidazolidin-2-ylidene)-2-methylsulfanyl-3,5-dihydro-imidazol-4-ones 4a-c using ketene dithioacetal intermediates 3a-c is described. The reactivity of thiohydantoin derivatives 2a-c towards N,N-dimethylformamide diethylacetal (DMF-DEA) was also explored using solvent-free technique under microwave irradiation (mu omega). The (1)H- and (13)C-NMR spectra of some representative products are discussed.

摘要

描述了一种使用乙烯酮二硫代缩醛中间体3a - c合成5 -（咪唑烷-2 -亚基）- 2 -甲硫基- 3,5 -二氢咪唑- 4 -酮4a - c的新路线。还利用微波辐射（μω）下的无溶剂技术研究了硫代乙内酰脲衍生物2a - c对N，N -二甲基甲酰胺二乙缩醛（DMF - DEA）的反应活性。讨论了一些代表性产物的¹H - 和¹³C - NMR光谱。

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