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The Saccharomyces cerevisiae histone acetyltransferase Gcn5 has a role in the photoreactivation and nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers in the MFA2 gene.酿酒酵母组蛋白乙酰转移酶Gcn5在MFA2基因中紫外线诱导的环丁烷嘧啶二聚体的光复活和核苷酸切除修复中发挥作用。
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本文引用的文献

1
Rad4-Rad23 interaction with SWI/SNF links ATP-dependent chromatin remodeling with nucleotide excision repair.Rad4-Rad23与SWI/SNF的相互作用将ATP依赖的染色质重塑与核苷酸切除修复联系起来。
Nat Struct Mol Biol. 2006 Oct;13(10):902-7. doi: 10.1038/nsmb1152. Epub 2006 Oct 1.
2
Five repair pathways in one context: chromatin modification during DNA repair.同一背景下的五条修复途径：DNA修复过程中的染色质修饰
Biochem Cell Biol. 2006 Aug;84(4):490-504. doi: 10.1139/o06-075.
3
Transcriptional repression by Tup1-Ssn6.由Tup1-Ssn6介导的转录抑制
Biochem Cell Biol. 2006 Aug;84(4):437-43. doi: 10.1139/o06-073.
4
Distinct functions of the ubiquitin-proteasome pathway influence nucleotide excision repair.泛素-蛋白酶体途径的不同功能影响核苷酸切除修复。
EMBO J. 2006 Jun 7;25(11):2529-38. doi: 10.1038/sj.emboj.7601120.
5
UV irradiation stimulates histone acetylation and chromatin remodeling at a repressed yeast locus.紫外线照射可刺激酵母中一个受抑制基因座处的组蛋白乙酰化和染色质重塑。
Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8650-5. doi: 10.1073/pnas.0501458102. Epub 2005 Jun 6.
6
The yeast Rad7/Rad16/Abf1 complex generates superhelical torsion in DNA that is required for nucleotide excision repair.酵母Rad7/Rad16/Abf1复合物在DNA中产生超螺旋扭转，这是核苷酸切除修复所必需的。
DNA Repair (Amst). 2004 Mar 4;3(3):277-87. doi: 10.1016/j.dnarep.2003.11.004.
7
Dissecting transcription-coupled and global genomic repair in the chromatin of yeast GAL1-10 genes.剖析酵母GAL1-10基因染色质中的转录偶联修复和全基因组修复
J Biol Chem. 2004 Apr 2;279(14):14418-26. doi: 10.1074/jbc.M312004200. Epub 2004 Jan 19.
8
Dynamics of histone acetylation in vivo. A function for acetylation turnover?体内组蛋白乙酰化的动力学。乙酰化周转的功能？
Biochem Cell Biol. 2002;80(3):363-78. doi: 10.1139/o02-080.
9
The Saccharomyces cerevisiae histone acetyltransferase Gcn5 has a role in the photoreactivation and nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers in the MFA2 gene.酿酒酵母组蛋白乙酰转移酶Gcn5在MFA2基因中紫外线诱导的环丁烷嘧啶二聚体的光复活和核苷酸切除修复中发挥作用。
J Mol Biol. 2002 Feb 22;316(3):489-99. doi: 10.1006/jmbi.2001.5383.
10
The mapping of nucleosomes and regulatory protein binding sites at the Saccharomyces cerevisiae MFA2 gene: a high resolution approach.酿酒酵母MFA2基因核小体与调控蛋白结合位点的图谱绘制：一种高分辨率方法。
Nucleic Acids Res. 2001 Jul 1;29(13):E64-4. doi: 10.1093/nar/29.13.e64.

酿酒酵母Rad16介导高效全基因组核苷酸切除修复所需的紫外线依赖性组蛋白H3乙酰化。

Saccharomyces cerevisiae Rad16 mediates ultraviolet-dependent histone H3 acetylation required for efficient global genome nucleotide-excision repair.

作者信息

Teng Yumin, Liu Hairong, Gill Hefin W, Yu Yachuan, Waters Raymond, Reed Simon H

机构信息

Department of Pathology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK.

出版信息

EMBO Rep. 2008 Jan;9(1):97-102. doi: 10.1038/sj.embor.7401112. Epub 2007 Nov 9.

DOI:10.1038/sj.embor.7401112
PMID:18007656
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2246617/
Abstract

In yeast, global genome nucleotide-excision repair (GG-NER) requires a protein complex containing Rad7 and Rad16. Rad16 is a member of the switch/sucrose nonfermentable superfamily, and it is presumed that chromatin remodelling is its primary function during repair. We show that RAD16 is required for ultraviolet-dependent hyperacetylation of histone H3 (Lys 9 and Lys 14) at the MFA2 promoter and throughout the genome. The yeast repressor complex Ssn6-Tup1 represses many genes including MFA2. TUP1 deletion results in constitutive hyperacetylation of histone H3, nucleosome disruption and derepression of gene transcription in Tup1-regulated genes. GG-NER in the MFA2 promoter proceeds more rapidly in tup1Delta alpha-cells compared with wild type, even when transcription is inhibited. We show that elevated histone H3 acetylation levels in the MFA2 promoter in tup1Delta alpha-cells result in Rad7- and Rad16-independent GG-NER, and that Rad16 mediates the ultraviolet-induced acetylation of histone H3, necessary for efficient GG-NER.

摘要

在酵母中，全基因组核苷酸切除修复（GG-NER）需要一种包含Rad7和Rad16的蛋白质复合物。Rad16是开关/蔗糖非发酵超家族的成员，据推测染色质重塑是其在修复过程中的主要功能。我们发现，RAD16是MFA2启动子及整个基因组中组蛋白H3（赖氨酸9和赖氨酸14）紫外线依赖性超乙酰化所必需的。酵母阻遏复合物Ssn6-Tup1可抑制包括MFA2在内的许多基因。TUP1缺失导致组蛋白H3组成型超乙酰化、核小体破坏以及Tup1调控基因的转录去抑制。与野生型相比，即使在转录受到抑制时，MFA2启动子中的GG-NER在tup1Δα细胞中也进行得更快。我们发现，tup1Δα细胞中MFA2启动子中组蛋白H3乙酰化水平升高导致了不依赖Rad7和Rad16的GG-NER，并且Rad16介导了高效GG-NER所必需的紫外线诱导的组蛋白H3乙酰化。