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Stem cells in the hair follicle and interfollicular epidermis of mice following topical application of fluocinolone acetonide.

作者信息

Morris R J

机构信息

Department of Dermatology, Columbia University, New York, New York 10032, USA.

出版信息

J Invest Dermatol. 2007 Dec;127(12):2707-8. doi: 10.1038/sj.jid.5701053.

DOI:10.1038/sj.jid.5701053
PMID:18007689
Abstract

One of the major adverse reactions to chronic treatment with glucocorticoids is cutaneous atrophy followed by resistance to continued treatment. Chebotaev et al. report that keratinocytes from both the hair follicle bulge and interfollicular epidermis of mice express the glucocorticoid receptor. Unexpectedly, however, bulge keratinocytes appeared to develop resistance more slowly than interfollicular keratinocytes, and appeared not to contribute to the repair of the atrophic epithelium.

摘要

相似文献

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Stem cells in the hair follicle and interfollicular epidermis of mice following topical application of fluocinolone acetonide.
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2
Epithelial cells in the hair follicle bulge do not contribute to epidermal regeneration after glucocorticoid-induced cutaneous atrophy.糖皮质激素诱导的皮肤萎缩后，毛囊隆突部的上皮细胞对表皮再生无贡献。
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Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids.激肽释放酶6在角质形成细胞对局部糖皮质激素产生增殖抵抗的过程中起重要作用。
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