Palmer A C, Jackson P G, Blakemore W F
Wellcome Laboratory for Comparative Neurology, School of Veterinary Medicine, Cambridge.
Neuropathol Appl Neurobiol. 1991 Dec;17(6):457-67. doi: 10.1111/j.1365-2990.1991.tb00749.x.
The clinical signs and neuropathological changes are described in six Limousin X calves that, at about one month after birth, showed signs of blindness, nystagmus, rotation of the eyes, opisthotonos, hyperprotraction of the forelegs and, in one case, apparent seizures. Pathologically there was necrosis of the optic chiasma and focal areas of myelin sheath vacuolation or demyelination in certain areas of the brain, especially in the cerebellar peduncles. In one animal, kept alive for 7 months, there was remyelination by Schwann cells of some demyelinated axons in the focal cerebellar lesions, while other axons remained demyelinated. There was no evidence of oligodendrocyte remyelination. The cause of the condition was not determined but a genetic association is likely.
对6头利木赞杂交犊牛的临床症状和神经病理学变化进行了描述。这些犊牛在出生后约1个月时出现失明、眼球震颤、眼球转动、角弓反张、前肢过度伸展症状，其中1头有明显癫痫发作。病理检查发现视交叉坏死，大脑某些区域，尤其是小脑脚出现局灶性髓鞘空泡化或脱髓鞘。1头存活7个月的动物，小脑局灶性病变中一些脱髓鞘轴突由施万细胞进行了再髓鞘化，而其他轴突仍处于脱髓鞘状态。没有少突胶质细胞再髓鞘化的证据。该病病因尚未确定，但可能与遗传有关。
