Scalzo F M, Myers M M
Department of Developmental Psychobiology, New York State Psychiatric Institute, NY.
Physiol Behav. 1991 Sep;50(3):525-31. doi: 10.1016/0031-9384(91)90540-5.
The effects of hexamethonium, a ganglionic blocker, on blood pressure (BP) and heart rate (HR) responses to milk ingestion were assessed in awake, 15-day-old spontaneously hypertensive rats (SHR) and their normotensive progenitor strain, Wistar-Kyoto rats (WKY) using two methods of milk delivery. SHRs had larger increases in BP compared to WKYs, but WKYs exhibited larger increases in HR following milk ingestion from an anesthetized dam. BP responses to milk ingestion from a tongue cannula were also larger in SHRs. Administration of hexamethonium prior to milk delivery resulted in a drop in BP following milk ingestion in both milk delivery situations for each strain. The results suggest that SHRs exhibit exaggerated sympathetic activation to milk ingestion compared to WKYs, and that in both strains, cardiovascular responses to feeding are modulated by the presence of the dam.
使用两种乳汁输送方法，评估了神经节阻滞剂六甲铵对清醒的15日龄自发性高血压大鼠（SHR）及其血压正常的亲代品系Wistar-Kyoto大鼠（WKY）的血压（BP）和心率（HR）对乳汁摄入反应的影响。与WKY相比，SHR的血压升高幅度更大，但从麻醉的母鼠摄取乳汁后，WKY的心率升高幅度更大。SHR对通过舌套管摄取乳汁的血压反应也更大。在每种品系的两种乳汁输送情况下，在输送乳汁前给予六甲铵都会导致摄取乳汁后血压下降。结果表明，与WKY相比，SHR对乳汁摄入表现出过度的交感神经激活，并且在两个品系中，对进食的心血管反应都受到母鼠存在的调节。
