Stengård J H, Stenbäck F, Saarni H U, Rautio A, Sotaniemi E A
National Public Health Institute, Helsinki, Finland.
Res Commun Chem Pathol Pharmacol. 1991 Oct;74(1):25-37.
The present study demonstrates that MPA treatment may alter liver ultrastructure in rats. This was seen as a slight cytoplasmic vacuolization in light microscopy. In electron microscopy the most striking findings were the increase in the size of hepatocytes, the volume of smooth endoplasmic reticulum (SER) and the number of mitochondria. Minor changes in mitochondrial size and structure, and SER outline were also obtained. The amount of rough endoplasmic reticulum was decreased and bleb formation was common. The effect of MPA on liver ultrastructure was time-dependent. The main changes were found in rats receiving MPA daily for seven days. Most of the observed changes disappeared within 17 days after the cessation of the regimen. MPA induced alterations in liver morphology may partly be due to induction phenomenon although the hormonal property of MPA also may play some etiological role.
本研究表明，霉酚酸酯（MPA）治疗可能会改变大鼠肝脏的超微结构。这在光学显微镜下表现为轻微的细胞质空泡化。在电子显微镜下，最显著的发现是肝细胞大小增加、滑面内质网（SER）体积增大以及线粒体数量增多。线粒体大小和结构以及SER轮廓也有轻微变化。粗面内质网数量减少，泡状形成常见。MPA对肝脏超微结构的影响具有时间依赖性。主要变化见于每天接受MPA治疗7天的大鼠。在治疗方案停止后的17天内，大多数观察到的变化消失。MPA诱导的肝脏形态改变可能部分归因于诱导现象，尽管MPA的激素特性也可能起一些病因学作用。
