Simarro P P, Sima F O, Mir M, Ndong P
Schistosomiasis Project, Agencia Español Cooperación Internacional AECI, Ministerio de Sanidad de Guinea Ecuatorial.
Trop Med Parasitol. 1991 Sep;42(3):167-71.
A longitudinal community-based study was carried out in order to evaluate the impact of repeated selective population chemotherapy with praziquantel on the epidemiology of an urban focus of Schistosoma intercalatum in the city of Bata, capital of the Continental Region of Equatorial Guinea. Three surveys were undertaken in January of 1988, 1989 and 1990, determining parasitological prevalence, intensity of infection and morbidity and applying repeated targeted mass treatment. One dose of praziquantel (40 mg/kg body weight) was given one week after treatment with mebendazole (100 mg every 12 hours for 3 days). A reduction of the overall prevalence by S. intercalatum of 69.9% and 79.3% in the first and second year respectively was found. Persons showing high parasite burden suffered a reduction of 95.7%. The cure rate (no more eggs in stool) was between 90% and 98.9%. A significant decrease of signs and symptoms was observed. No important side effects were detected. This study shows the positive action of praziquantel in reducing prevalence, intensity of infection and morbidity due to S. intercalatum, above all in the case of a high human population participation response. Cure rates obtained being similar to the ones observed using the same drug in Schistosoma mansoni and Schistosoma haematobium.
为了评估使用吡喹酮进行反复选择性群体化疗对赤道几内亚大陆地区首府巴塔市一个城市间插血吸虫病疫点流行病学的影响，开展了一项基于社区的纵向研究。1988年1月、1989年1月和1990年1月进行了三次调查，确定寄生虫学流行率、感染强度和发病率，并进行反复的针对性群体治疗。在用甲苯达唑治疗（100毫克，每12小时一次，共3天）一周后给予一剂吡喹酮（40毫克/千克体重）。发现第一年和第二年期间插血吸虫的总体流行率分别降低了69.9%和79.3%。寄生虫负荷高的人减少了95.7%。治愈率（粪便中无虫卵）在90%至98.9%之间。观察到体征和症状显著减少。未检测到重要的副作用。这项研究表明吡喹酮在降低间插血吸虫的流行率、感染强度和发病率方面具有积极作用，尤其是在人群参与度高的情况下。获得的治愈率与在曼氏血吸虫和埃及血吸虫中使用相同药物时观察到的治愈率相似。
