Allaerts W, Jeucken P H, Hofland L J, Drexhage H A
Department of Immunology, Erasmus University Rotterdam, The Netherlands.
Acta Endocrinol (Copenh). 1991;125 Suppl 1:92-7.
Lymphoid dendritic cells and pituitary folliculo-stellate cells have many morphological and immunocytochemical characteristics in common. They both have a stellate morphology, they are specifically detected by the presence of MHC class II determinants as well as the Ca(2+)-binding protein S100, they also produce the cytokine interleukin 6. A panel of monoclonal antibodies directed against murine and rat macrophages and/or dendritic cells was used to study the presence of dendritic and folliculo-stellate cells in the mouse and rat anterior pituitary. In the mouse pituitary stellate cells are detected with a monoclonal antibody against the dendritic cell aminopeptidase, but these cells display no S100 protein immunoreactivity. In the rat pituitary there were many S100 protein positive folliculo-stellate cells as well as a few macrophage-like cells, whereas stellate cells that express MHC class II markers were found in both mouse and rat anterior pituitaries. The present data suggest of a homology between lymphoid dendritic cells and pituitary folliculo-stellate cells, or at least a subgroup of the latter cells.
淋巴样树突状细胞和垂体滤泡星形细胞具有许多共同的形态学和免疫细胞化学特征。它们都具有星形形态，通过MHC II类决定簇以及钙结合蛋白S100的存在可特异性检测到它们，它们还产生细胞因子白细胞介素6。使用一组针对小鼠和大鼠巨噬细胞和/或树突状细胞的单克隆抗体来研究小鼠和大鼠垂体前叶中树突状细胞和滤泡星形细胞的存在情况。在小鼠垂体中，用针对树突状细胞氨肽酶的单克隆抗体可检测到星形细胞，但这些细胞不显示S100蛋白免疫反应性。在大鼠垂体中，有许多S100蛋白阳性的滤泡星形细胞以及一些巨噬细胞样细胞，而在小鼠和大鼠垂体前叶中均发现了表达MHC II类标志物的星形细胞。目前的数据表明淋巴样树突状细胞与垂体滤泡星形细胞之间存在同源性，或者至少是后者细胞中的一个亚群。
