Pfeffer M A, Pfeffer J M, Weiss A K, Frohlich E D
Am J Physiol. 1977 Jun;232(6):H639-644. doi: 10.1152/ajpheart.1977.232.6.H639.
Spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were treated with beta-adrenergic receptor inhibiting drugs (either propranolol or timolol) from conception until 12 weeks of age to determine if this therapy would alter the development of systemic hypertension or left ventricular hypertrophy. Therapy (propranolol or timolol, 500 mg/liter drinking water) was initiated with breeding parents and continued throughout the pregnancy, nursing, and postweaning periods. Although the heart rates of beta-adrenergic receptor inhibited WKY and SHR rats were consistently reduced with respect to their respective tap-water controls, this therapy did not alter body growth. Hemodynamic studies demonstrated reduced central venous pressure, cardiac index, and maximum acceleration of aortic flow in the beta-adrenergic inhibited rats. In spite of these findings, the arterial pressure of the treated rats and the degree of left ventricular hypertrophy of the SHR were unaltered by treatment. Thus, administration of the beta-adrenergic receptor blocking agents, propranolol or timolol, from conception through the developmental stage of SHR hypertension, failed to alter either the progressive rise in arterial pressure or the development of hypertensive vascular disease and left ventricular hypertrophy.
从受孕开始直至12周龄，对自发性高血压（SHR）大鼠和Wistar - Kyoto（WKY）大鼠使用β - 肾上腺素能受体抑制药物（普萘洛尔或噻吗洛尔）进行治疗，以确定这种治疗方法是否会改变系统性高血压或左心室肥厚的发展。治疗（普萘洛尔或噻吗洛尔，500毫克/升饮用水）从亲代繁殖开始，贯穿整个孕期、哺乳期和断奶后期。尽管与各自饮用自来水的对照组相比，β - 肾上腺素能受体受抑制的WKY和SHR大鼠的心率持续降低，但这种治疗并未改变身体生长情况。血流动力学研究表明，β - 肾上腺素能受抑制的大鼠中心静脉压、心脏指数和主动脉血流最大加速度降低。尽管有这些发现，但治疗并未改变治疗组大鼠的动脉血压以及SHR大鼠的左心室肥厚程度。因此，从受孕到SHR高血压发展阶段给予β - 肾上腺素能受体阻滞剂普萘洛尔或噻吗洛尔，未能改变动脉血压的逐渐升高，也未能改变高血压性血管疾病和左心室肥厚的发展。
