Velásquez-Pérez Leora, Rembao-Bojorquez Daniel, Guevara Jorge, Guadarrama-Torres Rosa María, Trejo-Contreras Araceli
Department of Epidemiology, National Institute of Neurology and Neurosurgery, Mexico DF, Mexico.
Neuropathology. 2007 Oct;27(5):419-28. doi: 10.1111/j.1440-1789.2007.00807.x.
Creutzfeldt-Jakob disease (CJD) is classified within the group of transmissible spongiform encephalopathies (TSE). It is a rapidly progressive illness that affects mental functions. The average age of onset is 50 years. Various tests can help orient the clinical diagnosis, but the confirmatory test is still the post mortem analysis. The aim of this study was to describe the epidemiological, clinical and histopathological characteristics of patients diagnosed as suffering from CJD, at the National Institute of Neurology and Neurosurgery of Mexico (NINN). An observational, descriptive and transversal study was conducted. We collected information concerning these cases from the Departments of Epidemiology and Pathology, as well as the clinical charts of the patients with a diagnosis of CJD. Fifteen cases were registered of which three CJD cases were definite, five probable cases were identified, and seven were possible. The average age of the patients was 49 years. Two definite cases were female and one was male. It is important to improve the systems for surveillance of this type of disease and, furthermore, to permit greater accessibility to laboratories where the procedures necessary for supporting diagnosis can be followed.
克雅氏病（CJD）归类于传染性海绵状脑病（TSE）。它是一种影响精神功能的快速进展性疾病。平均发病年龄为50岁。各种检查有助于临床诊断的导向，但确诊检查仍是尸检分析。本研究的目的是描述在墨西哥国家神经病学和神经外科研究所（NINN）被诊断为患有CJD的患者的流行病学、临床和组织病理学特征。进行了一项观察性、描述性和横断面研究。我们从流行病学和病理学部门收集了有关这些病例的信息，以及诊断为CJD患者的临床病历。登记了15例病例，其中3例为确诊的CJD病例，5例为可能病例，7例为疑似病例。患者的平均年龄为49岁。2例确诊病例为女性，1例为男性。改善这类疾病的监测系统很重要，此外，要使支持诊断所需程序的实验室更易使用。
