Inukai Kouichi, Awata Takuya, Katayama Shigehiro
Division of Endocrinology and Diabetes, Department of Internal Medicine, Saitama Medical University.
Nihon Rinsho. 2007 Nov;65(11):2125-30.
Two adiponectin receptors were recently identified, AdipoR1 and R2. AdipoR1 expression was increased approximately 2.5-fold in muscle tissues from insulin-deficient diabetic mice, but normalized with insulin administration. AdipoR1 expression was decreased by 44% in insulin-resistant obese, as compared to lean, mice. These results indicate AdipoR1 expression to correlate inversely with plasma insulin levels. Insulin treatment for 24 h decreased AdipoR1 expression by approximately 60% in C2C12 myocytes. In addition, this effect was mediated by the phosphatidylinositol-3 kinase/Foxo 1 dependent pathway. In contrast, AdipoR2 expression was not significantly altered in diabetic states. Our results indicate that regulation of AdipoR1, but not AdipoR2, may be involved in glucose and lipid metabolism in diabetic states.
最近发现了两种脂联素受体，即AdipoR1和R2。在胰岛素缺乏的糖尿病小鼠的肌肉组织中，AdipoR1的表达增加了约2.5倍，但在给予胰岛素后恢复正常。与瘦小鼠相比，胰岛素抵抗的肥胖小鼠中AdipoR1的表达降低了44%。这些结果表明AdipoR1的表达与血浆胰岛素水平呈负相关。在C2C12肌细胞中，胰岛素处理24小时可使AdipoR1的表达降低约60%。此外，这种作用是由磷脂酰肌醇-3激酶/Foxo 1依赖性途径介导的。相比之下，在糖尿病状态下AdipoR2的表达没有显著改变。我们的结果表明，在糖尿病状态下，AdipoR1而非AdipoR2的调节可能参与了葡萄糖和脂质代谢。
