Hodgson Richard, Bushe Chris, Hunter Robert
Lyme Brook Centre, Stoke on Trent, UK.
Br J Psychiatry Suppl. 2007 Aug;50:s78-84. doi: 10.1192/bjp.191.50.s78.
Randomised controlled trials (RCTs) are the gold standard for evaluating treatment efficacy. However, the outcomes of RCTs often lack clinical utility and usually do not address real-world effectiveness.
To review how traditional RCTs may be triangulated with other methodologies such as observational studies and pragmatic trials by highlighting recently reported studies, outcomes used and their respective merits.
Literature review focusing on drug treatment.
Recently reported observational and some pragmatic studies show a degree of consistency in reported results and use outcomes that have face validity for clinicians.
No single experimental paradigm or outcome provides the necessary data to optimise treatment of mental illness in the clinical setting.
随机对照试验（RCTs）是评估治疗效果的金标准。然而，RCTs的结果往往缺乏临床实用性，通常也无法解决实际疗效问题。
通过强调最近报道的研究、所使用的结果及其各自的优点，综述如何将传统的RCTs与其他方法（如观察性研究和实用性试验）相结合。
聚焦药物治疗的文献综述。
最近报道的观察性研究和一些实用性研究在报告结果上显示出一定程度的一致性，并使用了对临床医生具有表面效度的结果。
没有单一的实验范式或结果能提供必要的数据来优化临床环境中精神疾病的治疗。
