Gahn G, Hallmeyer-Elgner U, Becker S, Barrett K M, Ackermann R H
Klinik und Poliklinik für Neurologie, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany.
Vasa. 2007 Aug;36(3):181-4. doi: 10.1024/0301-1526.36.3.181.
To evaluate the timecourse of cerebrovascular reserve response to breath-holding.
Using simultaneous bilateral transcranial Doppler (TCD) recordings from the MCA during a breath-holding challenge, we measured the time interval between baseline and peak blood flow velocity values in 25 patients with critical unilateral internal carotid artery (ICA) stenosis (> 85% lumen diameter reduction), in 9 patients with a non-critical (70-85%) ICA-stenosis and in 27 normal controls.
Normal controls and patients with non-critical stenosis reached peak MCA velocities on both sides almost simultaneously. For the patients with critical stenosis the peak response time ipsilateral to the stenosis was delayed 2.40 +/- 3.43 sec compared to the opposite side. This delay resolved after carotid endarterectomy.
In response to a breath-holding challenge unilateral critical ICA stenosis is associated with a significant ipsilateral prolongation of the rise time from baseline to peak MCA velocity.
评估脑血管储备对屏气反应的时间过程。
在屏气激发试验期间，使用双侧同步经颅多普勒（TCD）记录大脑中动脉（MCA）血流，我们测量了25例单侧颈内动脉（ICA）严重狭窄（管腔直径减少>85%）患者、9例ICA非严重狭窄（70 - 85%）患者和27例正常对照者从基线到血流速度峰值的时间间隔。
正常对照者和ICA非严重狭窄患者双侧MCA几乎同时达到峰值速度。对于严重狭窄患者，狭窄同侧的峰值反应时间比另一侧延迟2.40±3.43秒。这种延迟在颈动脉内膜切除术后消失。
在屏气激发试验中，单侧ICA严重狭窄与从基线到MCA峰值速度的上升时间同侧显著延长有关。
