Kawano Youichi, Akimaru Koho, Taniai Nobuhiko, Yoshida Hiroshi, Yokomuro Shigeki, Mamada Yasuhiro, Mizuguchi Yoshiaki, Shimizu Tetsuya, Takahashi Tsubasa, Tajiri Takashi
Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, Graduate School of Medicine, Tokyo, 1-1-5 Sendagi, Bunkyou-ku, Tokyo 113-8603, Japan.
Hepatogastroenterology. 2007 Sep;54(78):1821-4.
Hepatic vein (HV) stenosis after liver transplantation is a rare but life-threatening complication that leads to graft loss. The incidence of HV stenosis after living-donor liver transplantation (LDLT) and split liver transplantation is not so rare, and is reported to range from 2 to 8.6%. Recently, the minimal invasiveness of radiologic interventions and the innovative techniques have led to their widespread adoption for the treatment of various complications after liver transplantation. We report a five-year-old boy with HV stenosis post-LDLT with only scarcity of clinical information including edema with hypoalbuminemia and elevated hyaluronic acid value. Doppler ultrasonography was effective to suggest stenosis, and angiography confirmed its diagnosis. The stenosis was successfully treated with balloon dilatation using interventional radiologic technique through the jugular vein. In conclusion, we suggest that if liver transplanted patients manifest ascites or/and edema with hypoalbuminemia and elevated hyaluronic acid in sera, HV stenosis should be suspected even if the other laboratory values are normal.
肝移植后肝静脉(HV)狭窄是一种罕见但危及生命的并发症,可导致移植物丢失。活体肝移植(LDLT)和劈离式肝移植后HV狭窄的发生率并非罕见,据报道为2%至8.6%。近来,放射介入治疗的微创性及创新技术已使其广泛应用于肝移植后各种并发症的治疗。我们报告了一名5岁LDLT术后发生HV狭窄的男孩,其临床资料仅有低白蛋白血症伴水肿及透明质酸值升高。多普勒超声有效地提示了狭窄,血管造影证实了诊断。通过颈静脉采用介入放射技术,经球囊扩张成功治疗了该狭窄。总之,我们建议,如果肝移植患者出现腹水或/和低白蛋白血症伴水肿以及血清透明质酸升高,即使其他实验室检查值正常,也应怀疑HV狭窄。