Vasilescu C, Taşcă C
Department of General Surgery, Fundeni Hospital, Bucharest, Romania.
Rom J Morphol Embryol. 1991 Jan-Jun;37(1-2):25-9.
In order to evaluate the systemic lesions during acute pancreatitis (AP) we produced the disease in rats by ligation of the common biliopancreatic duct. The animals were killed at 4, 24, 48 hours and at 7 days. Serum values of amylase appear increased 24 hours after common biliopancreatic duct ligation, decreased after 48 hours and remain at a low range at 7 days. The pancreatic lesions were: interstitial oedema, pancreatic ducts dilatation, necrosis, hemorrhages and extensive fat necroses in the peripancreatic area, retroperitoneum and mesentery. We also found signs of systemic damage, suggestive for a multiple organ failure syndrome in the lung (hemorrhages, neutrophils accumulation, microthromboses), stomach (erosive and hemorrhagic gastritis) and mild kidney hemorrhages. Thus we succeed in producing a pathological picture similar to the multiple organ failure syndrome (MOFS) lesions in a rat model by a mechanism similar to human biliary AP. This model could be useful in therapeutic studies and in further research in the field of pathogenesis of MOFS during AP.
为了评估急性胰腺炎（AP）期间的全身病变，我们通过结扎胆总管胰管在大鼠中制造了这种疾病。在4、24、48小时和7天时处死动物。胆总管胰管结扎24小时后血清淀粉酶值升高，48小时后降低，并在7天时保持在低水平。胰腺病变包括：间质水肿、胰管扩张、坏死、出血以及胰腺周围区域、腹膜后和肠系膜广泛的脂肪坏死。我们还发现了全身损伤的迹象，提示肺部（出血、中性粒细胞积聚、微血栓形成）、胃部（糜烂性和出血性胃炎）出现多器官功能衰竭综合征，以及轻度肾出血。因此，我们通过类似于人类胆源性AP的机制，成功在大鼠模型中产生了类似于多器官功能衰竭综合征（MOFS）病变的病理图像。该模型可用于治疗研究以及AP期间MOFS发病机制领域的进一步研究。
