单克隆B淋巴细胞增多症作为环境卫生研究中的一种生物标志物。

Monoclonal B-cell lymphocytosis as a biomarker in environmental health studies.

作者信息

Vogt Robert F, Shim Youn K, Middleton Dannie C, Buffler Patricia A, Campolucci Sharon S, Lybarger Jeffrey A, Marti Gerald E

机构信息

Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.

出版信息

Br J Haematol. 2007 Dec;139(5):690-700. doi: 10.1111/j.1365-2141.2007.06861.x.

DOI:10.1111/j.1365-2141.2007.06861.x

PMID:18021083

Abstract

The first studies of monoclonal B-cell lymphocytosis (MBL) in the general population were conducted as part of environmental health investigations that began in 1991. MBL was observed as an unexpected finding when blood samples were immunophenotyped by two-colour flow cytometric methods in common use at that time. The initial observations led to a workshop in 1995, at which case definitions were considered and medical follow-up investigations were recommended. Medical follow-ups were conducted in 1997 and 2003. A total of eight cases of confirmed MBL and three cases of presumptive MBL were identified. This review summarizes the findings from those investigations and discusses the issues related to using MBL as a biomarker in environmental health research and population-based studies.

摘要

对普通人群中克隆性B淋巴细胞增多症（MBL）的首次研究是作为1991年开始的环境卫生调查的一部分进行的。当时，在对血液样本采用常用的双色流式细胞术进行免疫表型分析时，MBL被作为一个意外发现而观察到。最初的观察结果促成了1995年的一次研讨会，会上审议了病例定义并建议进行医学随访调查。分别在1997年和2003年进行了医学随访。共确定了8例确诊的MBL病例和3例疑似MBL病例。本综述总结了这些调查的结果，并讨论了在环境卫生研究和基于人群的研究中使用MBL作为生物标志物的相关问题。