Carmant Lionel
D.Clinique d'Epilepsie et Centre de Recherche sur lEpilepsie, Service de Neurologie, CHU Sainte-Justine, Université de Montréal, 3175, Côte Sainte-Catherine, Bureau A-714, Montréal, Québec, H3T 1C5 Canada.
Med Sci (Paris). 2007 Nov;23(11):929-33. doi: 10.1051/medsci/20072311929.
Epilepsy affects 1-2 % of the population. For 30 % of these patients, their syndrome will be refractory to medical treatment. To improve our understanding and treatment of the epilepsies, we need to develop clinically relevant animal models. As temporal lobe epilepsy is often preceded by prolonged febrile seizures and in our population associated with a focal cortical dysplasia, we hypothesised that an underlying predisposing anatomical lesion would predispose individuals to develop prolonged febrile seizures and that temporal lobe epilepsy would later develop. As predicted, all the lesioned animals developed prolonged febrile seizures, while all other control groups only showed simple febrile seizures. After a latent period, 86 % of the animals who had experienced a prolonged seizure developed spontaneously recurrent limbic seizures. We now need to understand the anatomical and electrophysiological changes underlying this new epilepsy model to try and develop more effective treatments for the condition.
癫痫影响着1%-2%的人口。在这些患者中，30%的人其综合征对药物治疗将无效。为了增进我们对癫痫的理解和治疗，我们需要开发具有临床相关性的动物模型。由于颞叶癫痫通常先有长时间的热性惊厥，并且在我们的人群中与局灶性皮质发育异常有关，我们推测潜在的易患解剖学病变会使个体易发生长时间的热性惊厥，随后会发展为颞叶癫痫。正如所预测的，所有有病变的动物都出现了长时间的热性惊厥，而所有其他对照组只表现出单纯的热性惊厥。经过一段潜伏期后，经历过长时间惊厥的动物中有86%自发出现复发性边缘叶癫痫发作。我们现在需要了解这种新癫痫模型背后的解剖学和电生理变化，以便尝试开发出针对该病症更有效的治疗方法。
