Scantlebury Morris H, Gibbs Steve A, Foadjo Berline, Lema Pablo, Psarropoulou Caterina, Carmant Lionel
Sainte-Justine Hospital, University of Montreal, Montreal, Quebec, Canada.
Ann Neurol. 2005 Jul;58(1):41-9. doi: 10.1002/ana.20512.
The atypical febrile seizure has important clinical implications because of its association with the mesial temporal lobe epilepsy syndrome, which is the most common of the intractable epilepsies. However, whether a causal relation exists between these conditions is currently unknown. We have previously shown that a focal cortical lesion induced in the neonatal rat predisposes to the development of atypical hyperthermic seizures. We show here that 86% of the lesion plus hyperthermia group experience development of spontaneous recurrent seizures recorded from the amygdala ipsilateral to the lesion. Control rats did not have spontaneous recurrent behavioral or electrographic seizures. Lesioned rats with hyperthermic seizures also showed an impaired performance on the Morris water maze when compared with naive control rats, suggesting mild deficits in learning and memory. These findings support a link between the atypical febrile seizure and mesial temporal lobe epilepsy, and at the same time establish a new model for this condition through which new preventative and therapeutic strategies can be tested.
非典型热性惊厥具有重要的临床意义，因为它与内侧颞叶癫痫综合征相关，而内侧颞叶癫痫综合征是最常见的难治性癫痫。然而，目前尚不清楚这些病症之间是否存在因果关系。我们之前已经表明，新生大鼠诱发的局灶性皮质病变易引发非典型高热惊厥。我们在此表明，病变加高热组中86%的大鼠出现了从病变同侧杏仁核记录到的自发性复发性惊厥。对照大鼠没有自发性复发性行为或脑电图惊厥。与未处理的对照大鼠相比，患有高热惊厥的病变大鼠在莫里斯水迷宫实验中的表现也受损，这表明其学习和记忆存在轻度缺陷。这些发现支持了非典型热性惊厥与内侧颞叶癫痫之间的联系，同时建立了一种针对这种病症的新模型，通过该模型可以测试新的预防和治疗策略。
