Issac Tim T, Dokainish Hisham, Lakkis Nasser M
Division of Cardiology, Baylor College of Medicine, Houston, Texas, USA.
J Am Coll Cardiol. 2007 Nov 20;50(21):2021-8. doi: 10.1016/j.jacc.2007.06.054. Epub 2007 Nov 5.
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Recent studies have indicated that inflammation might play a significant role in the initiation, maintenance, and perpetuation of AF. Inflammatory markers such as interleukin-6 and C-reactive protein are elevated in AF and correlate to longer duration of AF, success of cardioversion, and thrombogenesis. Furthermore, the inflammatory process might be modulated by the use of statins, angiotensin-converting enzyme inhibitors, or glucocorticoids. The purpose of this study is to analyze the current published reports on the relationship between inflammation and AF and the potential therapeutic options available to modulate the inflammatory milieu in AF.
心房颤动（AF）是临床实践中最常见的心律失常。最近的研究表明，炎症可能在房颤的起始、维持和持续中起重要作用。炎症标志物如白细胞介素-6和C反应蛋白在房颤患者中升高，且与房颤持续时间延长、复律成功率及血栓形成相关。此外，使用他汀类药物、血管紧张素转换酶抑制剂或糖皮质激素可能会调节炎症过程。本研究的目的是分析当前已发表的关于炎症与房颤关系的报告，以及调节房颤炎症环境的潜在治疗选择。
