Tschachler Erwin
Department of Dermatology, Medical University of Vienna, A-1090 Vienna, Austria.
Clin Dermatol. 2007 Nov-Dec;25(6):589-95. doi: 10.1016/j.clindermatol.2007.09.021.
Besides the infiltrate of immune cells in psoriatic lesions, the principal characteristic changes in the skin are changes of the epidermal architecture and alterations of keratinocyte differentiation, which are distinct from other inflammatory skin diseases clinically and histologically. Several lines of evidence suggest that 3 of the 9 psoriasis susceptibility loci identified today might play a role in the keratinocyte differentiation program. Therefore, besides the dysregulation of the immune system, intrinsic epidermal components are also likely to play a role in triggering and/or sustaining the disease process and contribute to the chronicity of psoriasis and its frequent relapses.
除了银屑病皮损中有免疫细胞浸润外，皮肤的主要特征性变化是表皮结构的改变和角质形成细胞分化的改变，这在临床和组织学上都与其他炎症性皮肤病不同。几条证据表明，如今确定的9个银屑病易感基因座中的3个可能在角质形成细胞分化程序中起作用。因此，除了免疫系统失调外，表皮内在成分也可能在触发和/或维持疾病过程中起作用，并导致银屑病的慢性病程及其频繁复发。
