Ziemlański S, Wartanowicz M, Potrzebnicka K, Burgos de Moor A, Iwanow K, Ignatowska-Switalska M, Zelakiewicz K
Department of Nutrition Physiology and Biochemistry, National Food and Nutrition Institute, Warsaw, Poland.
Nutrition. 1991 Mar-Apr;7(2):131-5; discussion 135-6.
The effects of exogenous ascorbic acid on the development of experimental hypertension and on calcium, sodium, and potassium metabolism have been studied. The investigation was carried out in 90 4-mo-old male Wistar rats fed high- and low-fat diets. Hypertension was induced by administering a 1.5% solution of NaCl orally. Some rats received 0.1% ascorbic acid in distilled water orally for the first 7 wk of the experiment, then 0.3% for the next 5 wk. The results showed that the amount of fat, NaCl, and ascorbate in the diet may play a role in the etiopathogenesis of hypertension. A high-fat high-NaCl diet increased blood pressure more than a low-fat high-NaCl diet. Additional intake of 0.3% ascorbate solution reduced experimentally induced hypertension by 4% with a low-fat diet and by 14% with a high-fat diet. Also, 0.3% ascorbate solution had a blood-pressure-lowering effect in rats fed a high-fat diet without NaCl. Supplementation with ascorbate diminished urine calcium output with a high-fat diet and increased the urine PGE2/PGF2 ratio with both low- and high-fat diets.
研究了外源性抗坏血酸对实验性高血压发展以及钙、钠和钾代谢的影响。研究在90只4月龄雄性Wistar大鼠中进行，这些大鼠分别喂食高脂和低脂饮食。通过口服1.5%的氯化钠溶液诱导高血压。在实验的前7周，一些大鼠口服0.1%抗坏血酸的蒸馏水，接下来5周口服0.3%抗坏血酸的蒸馏水。结果表明，饮食中脂肪、氯化钠和抗坏血酸盐的含量可能在高血压的病因发病机制中起作用。高脂高盐饮食比低脂高盐饮食更能升高血压。额外摄入0.3%抗坏血酸溶液，低脂饮食时可使实验性高血压降低4%，高脂饮食时可降低14%。此外，0.3%抗坏血酸溶液对喂食高脂无盐饮食的大鼠有降压作用。补充抗坏血酸盐可减少高脂饮食大鼠的尿钙排出量，并增加低脂和高脂饮食大鼠的尿PGE2/PGF2比值。
