Meraïhi Z, Lutz O, Scheftel J M, Frey A, Ferezou J, Bach A C
Laboratoire, Clinique Médicale A, Hôpital Civil, Strasbourg, France.
Nutrition. 1991 Mar-Apr;7(2):93-7; discussion 98.
The clearance rate of endogenous and exogenous circulating lipids during the septic or inflammatory state remains a controversial subject. Thus, we have developed rat models of gram-negative and gram-positive sepsis and of sterile inflammation to study this problem. In addition to the febrile response, these stresses induced some of the following metabolic changes in the blood: decreased total protein, albumin, and ketone body levels and increased lactate, pyruvate, alanine, cholesterol, and triacylglycerol levels. The activities of heart, diaphragm, and adipose tissue lipoprotein lipase and of hepatic lipase decreased to differing extents depending on whether the enzyme substrate was a long-chain or a medium- and long-chain triglyceride-based emulsion. However, the latter emulsion was always hydrolyzed faster than the former. This observation suggests that, during infection/inflammation, the medium- and long-chain triglyceride-based emulsion would be cleared more quickly, would induce less hypertriglyceridemia, and would thus deliver lipid energy more rapidly than a traditional long-chain triglyceride-based emulsion.
在脓毒症或炎症状态下，内源性和外源性循环脂质的清除率仍是一个有争议的话题。因此，我们建立了革兰氏阴性和革兰氏阳性脓毒症以及无菌性炎症的大鼠模型来研究这个问题。除发热反应外，这些应激还在血液中引起了以下一些代谢变化：总蛋白、白蛋白和酮体水平降低，乳酸、丙酮酸、丙氨酸、胆固醇和三酰甘油水平升高。心脏、膈肌和脂肪组织脂蛋白脂肪酶以及肝脂肪酶的活性根据酶底物是基于长链还是中长链甘油三酯的乳剂而有不同程度的降低。然而，后者的乳剂总是比前者水解得更快。这一观察结果表明，在感染/炎症期间，基于中长链甘油三酯的乳剂将被更快清除，引起的高甘油三酯血症更少，因此比传统的基于长链甘油三酯的乳剂能更快地提供脂质能量。
