Caceres Javier F, Misteli Tom
MRC Human Genetics Unit, Edinburgh, UK.
Cell. 2007 Nov 16;131(4):645-7. doi: 10.1016/j.cell.2007.11.001.
There are two molecular machineries for pre-mRNA splicing-the major spliceosome and the minor spliceosome. In this issue of Cell, König et al. (2007) demonstrate that the two splicing pathways are spatially separated in the cell and may have distinct functions.