帕金森病性tau蛋白病中的视幻觉和快速眼动睡眠行为障碍症状
Visual hallucinations and symptoms of REM sleep behavior disorder in Parkinsonian tauopathies.
作者信息
Diederich Nico J, Leurgans Sue, Fan Wenqing, Chmura Teresa A, Goetz Christopher G
机构信息
Department of Neurosciences, Centre Hospitalier de Luxembourg, Luxembourg-City, Luxembourg.
出版信息
Int J Geriatr Psychiatry. 2008 Jun;23(6):598-603. doi: 10.1002/gps.1945.
BACKGROUND
In Parkinsonism, visual hallucinations (VH) and REM sleep behavior disorder (RBD) have been thought to indicate underlying synucleinopathy.
OBJECTIVES
We tested the validity of this hypothesis by searching for VH and RBD symptoms in Parkinsonism related to tauopathies.
METHODS
Patients with progressive supranuclear palsy or corticobasal degeneration were identified via a clinical data bank.
RESULTS
Of 53 patients who expressed study interest by telephone, 44 returned questionnaires. VH occurred in 16% of patients. Similarly, acting out of dreams occurred in 16% of patients. Neither VH nor RBD symptoms were linked to disease duration or dopaminergic medication and there was no mutual association.
CONCLUSION
VH and RBD symptoms also occur in Parkinsonism related to tauopathies, thus refuting the initial hypothesis.
背景
在帕金森综合征中，视幻觉（VH）和快速眼动睡眠行为障碍（RBD）被认为提示潜在的突触核蛋白病。
目的
我们通过在与tau蛋白病相关的帕金森综合征中寻找VH和RBD症状来检验这一假设的有效性。
方法
通过临床数据库识别进行性核上性麻痹或皮质基底节变性患者。
结果
在53名通过电话表示有研究兴趣的患者中，44名返回了问卷。16%的患者出现视幻觉。同样，16%的患者出现梦境行为。VH和RBD症状均与疾病持续时间或多巴胺能药物无关，且两者之间无相互关联。
结论
VH和RBD症状也出现在与tau蛋白病相关的帕金森综合征中，从而反驳了最初的假设。
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