核受体：解读代谢性疾病
Nuclear receptors: decoding metabolic disease.
作者信息
Sonoda Junichiro, Pei Liming, Evans Ronald M
机构信息
Howard Hughes Medical Institute, The Salk Institute for Biological Studies, 10010N. Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
FEBS Lett. 2008 Jan 9;582(1):2-9. doi: 10.1016/j.febslet.2007.11.016. Epub 2007 Nov 20.
Abstract
Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that regulate development, reproduction, and metabolism of lipids, drugs and energy. The importance of this family of proteins in metabolic disease is exemplified by NR ligands used in the clinic or under exploratory development for the treatment of diabetes mellitus, dyslipidemia, hypercholesterolemia, or other metabolic abnormalities. Genetic studies in humans and rodents support the notion that NRs control a wide variety of metabolic processes by regulating the expression of genes encoding key enzymes, transporters and other proteins involved in metabolic homeostasis. Current knowledge of complex NR metabolic networks is summarized here.
摘要
核受体（NR）是一类配体激活的转录因子超家族，可调节脂质、药物和能量的发育、繁殖及代谢。该蛋白家族在代谢性疾病中的重要性体现在临床上使用的或处于探索性开发阶段用于治疗糖尿病、血脂异常、高胆固醇血症或其他代谢异常的NR配体上。人类和啮齿动物的遗传学研究支持这样一种观点，即核受体通过调节编码参与代谢稳态的关键酶、转运蛋白和其他蛋白质的基因表达来控制多种代谢过程。本文总结了目前关于复杂核受体代谢网络的知识。
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