Gómez-Ochoa P, Castillo J A, Gascón M, Zarate J J, Alvarez F, Couto C G
Department of Animal Pathology, Veterinary Faculty of Zaragoza, c/ Miguel Servet 177, CP 50013 Zaragoza, Spain.
Vet J. 2009 Feb;179(2):259-63. doi: 10.1016/j.tvjl.2007.09.014. Epub 2007 Nov 19.
The aim of this study was to evaluate the effects of domperidone, a dopamine D2 receptor antagonist, in dogs naturally infected by Leishmania infantum. Ninety-eight dogs were treated with single-agent domperidone at 1mg/kg twice a day orally for 1 month. Clinical, serological, biochemical and immunological examinations were conducted for the following 12 months. Domperidone was effective in controlling and reducing clinical signs and antibody titre. Significant decreases in reciprocal serum antibodies were seen in 74.3% of the dogs with mild clinical signs and 40% of the dogs became seronegative. In dogs with several clinical signs and high antibody titres, clinical improvement occurred in 86% of animals and the reciprocal serum antibody titres decreased in 38% of these dogs. A significant increase was noted in the immune cellular status, as measured by the leishmanin skin test and a lymphocyte proliferation assay.
本研究的目的是评估多巴胺D2受体拮抗剂多潘立酮对自然感染婴儿利什曼原虫的犬的影响。98只犬每天口服1mg/kg的单剂多潘立酮，分两次给药，持续1个月。在接下来的12个月里进行了临床、血清学、生化和免疫学检查。多潘立酮在控制和减轻临床症状以及抗体滴度方面有效。74.3%有轻度临床症状的犬血清抗体效价显著降低，40%的犬血清学转为阴性。在有多种临床症状和高抗体滴度的犬中，86%的动物临床症状改善，其中38%的犬血清抗体效价降低。通过利什曼原虫皮肤试验和淋巴细胞增殖试验测定，免疫细胞状态显著增加。
