Greenway C V, Innes I R, Scott G D
Department of Pharmacology, University of Manitoba, Winnipeg, Canada.
Can J Physiol Pharmacol. 1991 Dec;69(12):1914-6. doi: 10.1139/y91-283.
In cats anesthetized with pentobarbital, hepatic venous pressure was increased to cause drops of exudate to appear on the surface of the liver. These drops were collected during steady-state infusions of small doses of ethanol and galactose when there was a large arteriovenous gradient across the liver. Comparison of the concentrations of these substances in arterial, portal, and hepatic venous blood and exudate showed that the exudate concentrations were slightly higher than the hepatic venous concentrations but markedly lower than arterial and portal blood concentrations. We conclude that the exudate cannot be entirely formed in the space of Mall (presinusoidal) but a substantial part is postsinusoidal in origin. If the exudate is a mixture of fluids equilibrated with inflowing and outflowing blood, then 75-80% of the exudate is postsinusoidal and 20-25% is presinusoidal in origin.
在用戊巴比妥麻醉的猫身上，增加肝静脉压力以使肝表面出现渗出液滴。当肝脏存在较大的动静脉梯度时，在小剂量乙醇和半乳糖的稳态输注期间收集这些液滴。对动脉血、门静脉血、肝静脉血和渗出液中这些物质浓度的比较表明，渗出液浓度略高于肝静脉浓度，但明显低于动脉血和门静脉血浓度。我们得出结论，渗出液并非完全在马洛间隙（窦前）形成，而是很大一部分起源于窦后。如果渗出液是与流入和流出血液平衡的液体混合物，那么75 - 80%的渗出液起源于窦后，20 - 25%起源于窦前。
