Bharat Ankit, Mohanakumar T
Department of Surgery, Washington University School of Medicine, Box 8109-3328 CSRB, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.
Cell Immunol. 2007 Jul;248(1):31-43. doi: 10.1016/j.cellimm.2007.03.010.
The inherent ability of the host immune system to distinguish between self- and non-self forms the basis of allorecognition. T lymphocytes constitute the most important effector arm of allorecognition. Here we describe the fundamentals of direct and indirect pathways by which allopeptides are presented to effector T cells. The nature of allopeptides presented along with tolerogenic strategies like altered peptide ligands and intra- or extra-thymic allopeptide inoculation are discussed. In addition, we speculate on the potential of regulatory T cells to modulate alloimmune responses.
宿主免疫系统区分自身与非自身的内在能力构成了同种异体识别的基础。T淋巴细胞是同种异体识别最重要的效应细胞群。在此，我们描述了同种异体肽呈递给效应T细胞的直接和间接途径的基本原理。讨论了与致耐受性策略（如改变的肽配体以及胸腺内或胸腺外同种异体肽接种）一起呈递的同种异体肽的性质。此外，我们推测了调节性T细胞调节同种异体免疫反应的潜力。
