Jallouli M, Frigui M, Marzouk S, Kaddour N, Kechaou M, Frikha F, Bahloul Z
Service de médecine interne, CHU Hédi-Chaker, 3029 Sfax, Tunisie.
Rev Med Interne. 2008 Apr;29(4):311-4. doi: 10.1016/j.revmed.2007.09.028. Epub 2007 Oct 22.
The most common renal disease in Sjögren's syndrome is tubulo-interstitial nephritis, responsible for tubular acidosis in around 20 % of patients. Osteomalacia exceptionally occurs as the first manifestation of a renal tubule disorder due to a Sjögren's syndrome.
We report a case of a 20-year-old woman with tubular acidosis induced osteomalacia secondary to primary Sjögren's syndrome. Improvement was obtained with bicarbonates, vitamin D, calcium and high-dose steroid therapy.
During Sjögren's syndrome, osteomalacia can complicate the distal renal tubular acidosis. In spite of the rare cases of osteomalacia revealing Sjögren's syndrome, this auto-immune disease must appear in the list of the aetiologies of osteomalacia.
干燥综合征中最常见的肾脏疾病是肾小管间质性肾炎，约20%的患者会因此出现肾小管酸中毒。骨软化症极少作为干燥综合征所致肾小管疾病的首发表现出现。
我们报告一例20岁女性，继发于原发性干燥综合征的肾小管酸中毒导致骨软化症。通过使用碳酸氢盐、维生素D、钙剂及大剂量类固醇治疗后病情得到改善。
在干燥综合征期间，骨软化症可使远端肾小管酸中毒复杂化。尽管骨软化症作为干燥综合征首发表现的病例罕见，但这种自身免疫性疾病仍应列入骨软化症的病因清单中。
