Sun He, Li Tie-Jun, Sun Lian-Na, Qiu Yan, Huang Bei-Bei, Yi Bo, Chen Wan-Sheng
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 GuoHe Road, Shanghai 200433, China.
J Ethnopharmacol. 2008 Jan 17;115(2):203-8. doi: 10.1016/j.jep.2007.09.026. Epub 2007 Oct 3.
In the present study, we investigate the effects of an extract isolated from traditional Chinese medicine Zi-Shen Pill (ZSPE) on benign prostatic hyperplasia (BPH) in rats induced by testosterone after castration. A total of 50 rats were equally divided into five groups: Group 1 served as control (sham-operated group); Group 2 was model group; Group 3 and Group 4 animals were administered with ZSPE at dose levels of 300 mg/kg and 600 mg/kg; Group 5 was served as positive control group and treated with finasteride at a dose of 1 mg/kg. The drugs were administered orally once a day for 28 days consecutively. The prostate weight, prostatic index, and serum dihydrotestosterone (DHT) levels were significantly reduced and the pathological changes in BPH were also by ameliorated ZSPE. Immunohistochemical examination revealed that the expressions of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in prostate were inhibited by ZSPE treatment, whereas the levels of transforming growth factor-beta1 (TGF-beta1) were increased. These results suggest that ZSPE has a definite inhibitory effect on BPH and might be an alternative medicine for treatment of human BPH.
在本研究中，我们探究了从中药紫参丸（ZSPE）中提取的提取物对去势后睾酮诱导的大鼠良性前列腺增生（BPH）的影响。总共50只大鼠被平均分为五组：第1组作为对照组（假手术组）；第2组为模型组；第3组和第4组动物分别给予300 mg/kg和600 mg/kg剂量的ZSPE；第5组作为阳性对照组，用1 mg/kg剂量的非那雄胺进行治疗。药物连续28天每天口服给药一次。ZSPE可显著降低前列腺重量、前列腺指数和血清双氢睾酮（DHT）水平，同时改善BPH的病理变化。免疫组织化学检查显示，ZSPE处理可抑制前列腺中血管内皮生长因子（VEGF）和碱性成纤维细胞生长因子（bFGF）的表达，而转化生长因子-β1（TGF-β1）水平升高。这些结果表明，ZSPE对BPH具有明确的抑制作用，可能是治疗人类BPH的替代药物。
