Uckun Fatih M, Tibbles Heather, Ozer Zahide, Qazi Sanjive, Vassilev Alexei
Parker Hughes Cancer Center, 2848 Patton Road, St. Paul, MN 55113, USA.
Bioorg Med Chem. 2008 Feb 1;16(3):1287-98. doi: 10.1016/j.bmc.2007.10.066. Epub 2007 Oct 24.
We examined the biologic activity of the rationally designed JAK3 inhibitor, JANEX-1, in several cellular and animal models of inflammation. Notably, JANEX-1 exhibited potent anti-inflammatory activity in each of these preclinical models, including mouse models of peritonitis, colitis, cellulitis, and systemic inflammatory response syndrome. Therefore, JANEX-1 may prove useful as a broad-spectrum anti-inflammatory agent. The present study may provide the basis for new and effective treatment as well as prevention programs for inflammatory disorders.
我们在多种细胞和动物炎症模型中研究了合理设计的JAK3抑制剂JANEX-1的生物活性。值得注意的是，JANEX-1在这些临床前模型中的每一个中都表现出强大的抗炎活性，包括腹膜炎、结肠炎、蜂窝织炎和全身炎症反应综合征的小鼠模型。因此，JANEX-1可能被证明是一种有用的广谱抗炎剂。本研究可能为炎症性疾病的新的有效治疗以及预防方案提供基础。
