美国黑人和白人之间补体成分C4的定量及抗原性差异。

Quantitative and antigenic differences in complement component C4 between American blacks and whites.

作者信息

Moulds J M, Warner N B, Arnett F C

机构信息

Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center, Houston.

出版信息

Complement Inflamm. 1991;8(5-6):281-7. doi: 10.1159/000463197.

DOI:10.1159/000463197

PMID:1802546

Abstract

A population of 98 healthy Black Americans was studied in order to determine normal ranges for total C4, C4A and C4B. Mean total C4 in Blacks measured by an enzymelinked immunoassay (EIA) was 44 +/- 12.8 mg/dl which was significantly different (p less than 0.001) from Caucasian levels of 31.7 +/- 11.5 mg/dl. The difference in total C4 was due to increased levels of C4B in Blacks (means = 24.4 mg/dl) as compared to Whites (means = 15.7 mg/dl; p less than 0.001). These results remained significantly different even when 8 samples having the C4A 91 phenotype were excluded. Since EIAs using monoclonal antibodies with Ch 1 specificity may yield false results, C4 allotyping is recommended when quantitating C4A and C4B levels in Blacks.

摘要

为了确定总C4、C4A和C4B的正常范围，对98名健康美国黑人进行了研究。通过酶联免疫分析（EIA）测得黑人的平均总C4为44±12.8mg/dl，与白种人的31.7±11.5mg/dl水平有显著差异（p<0.001）。总C4的差异是由于黑人中C4B水平升高（均值=24.4mg/dl），而白人中C4B水平为（均值=15.7mg/dl；p<0.001）。即使排除了8个具有C4A 91表型的样本，这些结果仍有显著差异。由于使用具有Ch 1特异性单克隆抗体的EIA可能产生错误结果，因此在定量黑人的C4A和C4B水平时，建议进行C4别型分析。