Ajami Bahareh, Bennett Jami L, Krieger Charles, Tetzlaff Wolfram, Rossi Fabio M V
University of British Columbia, The Biomedical Research Centre, 2222 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.
Nat Neurosci. 2007 Dec;10(12):1538-43. doi: 10.1038/nn2014. Epub 2007 Nov 18.
Microgliosis is a common response to multiple types of damage in the CNS. However, the origin of the cells involved in this process is still controversial and the relative importance of local expansion versus recruitment of microglia progenitors from the bloodstream is unclear. Here, we investigated the origin of microglia using chimeric animals obtained by parabiosis. We found no evidence of microglia progenitor recruitment from the circulation in denervation or CNS neurodegenerative disease, suggesting that maintenance and local expansion of microglia are solely dependent on the self-renewal of CNS resident cells in these models.
小胶质细胞增生是中枢神经系统对多种类型损伤的常见反应。然而，参与这一过程的细胞起源仍存在争议，并且局部增殖与从血液中募集小胶质细胞祖细胞的相对重要性尚不清楚。在此，我们利用联体共生获得的嵌合动物研究了小胶质细胞的起源。我们发现在去神经支配或中枢神经系统神经退行性疾病中，没有证据表明存在从循环系统募集小胶质细胞祖细胞的情况，这表明在这些模型中，小胶质细胞的维持和局部增殖完全依赖于中枢神经系统驻留细胞的自我更新。
