干扰素诱导解旋酶基因中的A946T多态性在中国人群中不会导致格雷夫斯病易感性。
The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to Graves' disease in Chinese population.
作者信息
Zhao Ze-Fei, Cui Bin, Chen Hao-Yan, Wang Shu, Li Imelda, Gu Xue-Jiang, Qi Li, Li Xiao-Ying, Ning Guang, Zhao Yong-Ju
机构信息
Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 197 Ruijin Er Lu, Shanghai, 200025, PR China.
出版信息
Endocrine. 2007 Oct;32(2):143-7. doi: 10.1007/s12020-007-9024-z. Epub 2007 Nov 17.
Genetic susceptibility plays a major role in the etiology of Graves' disease (GD). A recent study revealed that the A946T polymorphism (rs1990760) in interferon induced helicase (IFIH1) gene was a susceptible locus for GD. A case-control study in a Chinese population was undertaken, with 261 GD patients and 206 healthy subjects, to analyze the association of A946T polymorphism in IFIH1 gene with GD. In addition, the distribution of IFIH1 genotypes was investigated in subgroups according to the onset age and the Graves' ophthalmopathy (GO). No significant differences in the allele and genotype frequencies for A946T polymorphism were found between GD patients and healthy controls (chi2 = 2.834, P = 0.242; chi2 = 1.127, P = 0.288). The genotype-phenotype correlation was not identified either. Therefore we were unable to find the association of A946T polymorphism of the IFIH1 gene with the development of GD in a Chinese population.
遗传易感性在格雷夫斯病（GD）的病因中起主要作用。最近一项研究显示，干扰素诱导解旋酶（IFIH1）基因中的A946T多态性（rs1990760）是GD的一个易感位点。在中国人群中开展了一项病例对照研究，纳入261例GD患者和206名健康受试者，以分析IFIH1基因中A946T多态性与GD的关联。此外，根据发病年龄和格雷夫斯眼病（GO）在亚组中研究了IFIH1基因型的分布。GD患者与健康对照之间在A946T多态性的等位基因和基因型频率上未发现显著差异（χ2 = 2.834，P = 0.242；χ2 = 1.127，P = 0.288）。也未发现基因型与表型的相关性。因此，我们未能在中国人群中发现IFIH1基因的A946T多态性与GD发生之间的关联。
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