Shen Steven S, Lerner Seth P
Department of Pathology, The Methodist Hospital and Weill Medical College of Cornell University, 6565 Fannin Street, Houston, TX 77030, USA.
Expert Rev Anticancer Ther. 2007 Aug;7(8):1155-62. doi: 10.1586/14737140.7.8.1155.
Prostatic involvement by transitional cell carcinoma (pTCC) in patients with bladder cancer is a frequent finding, particularly in patients with high-grade invasive tumor and urothelial carcinoma in situ. Various patterns and levels of prostatic involvement have been described, and their impact in patients' management and their prognosis recognized. The role of prostatic urethral biopsy and intraoperative frozen section in the management of bladder cancer, tailoring to the bladder tumor stage is still not well defined and universally accepted. This review discusses the current understanding of the biology and histological patterns of pTCC and their clinical significance and management options. A rational approach for management of pTCC in patients with bladder cancer will be proposed on the basis of our experience and our review of literature.
膀胱癌患者中前列腺受移行细胞癌（pTCC）累及是常见现象，尤其是在高级别浸润性肿瘤和原位尿路上皮癌患者中。已描述了前列腺受累的各种模式和程度，并且认识到它们对患者治疗及预后的影响。前列腺尿道活检和术中冰冻切片在膀胱癌治疗中的作用，根据膀胱肿瘤分期进行调整，目前仍未明确界定且未被普遍接受。本综述讨论了目前对pTCC生物学及组织学模式的认识、它们的临床意义及治疗选择。基于我们的经验和文献综述，将提出一种针对膀胱癌患者中pTCC的合理管理方法。
