接受异基因干细胞移植的超重儿童预后较差。
Inferior outcomes for overweight children undergoing allogeneic stem cell transplantation.
作者信息
Bulley Sean, Gassas Adam, Dupuis L Lee, Aplenc Richard, Beyene Joseph, Greenberg Mark L, Doyle John J, Sung Lillian
机构信息
Division of Haematology/Oncology and Program in Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
出版信息
Br J Haematol. 2008 Jan;140(2):214-7. doi: 10.1111/j.1365-2141.2007.06900.x. Epub 2007 Nov 19.
This retrospective cohort study aimed at determining whether overweight children undergoing allogeneic stem cell transplantation (SCT) had inferior overall survival compared with children who were not overweight. Children >/=2 years of age who received allogeneic SCT were included. Overweight was defined as a body mass index >/= 95th percentile; 54/325 (17%) children were overweight. Overall survival at 5 years was significantly inferior at 46.6 +/- 7.3% in the overweight group compared with 59.5 +/- 3.2% in the non-overweight group (P = 0.02). Our study demonstrated that overweight children who undergo allogeneic SCT had inferior survival compared with children who were not overweight.
这项回顾性队列研究旨在确定接受异基因干细胞移植（SCT）的超重儿童与未超重儿童相比，总体生存率是否更低。纳入了年龄≥2岁且接受异基因SCT的儿童。超重定义为体重指数≥第95百分位数；54/325（17%）名儿童超重。超重组5年总体生存率显著低于非超重组，分别为46.6±7.3%和59.5±3.2%（P = 0.02）。我们的研究表明，接受异基因SCT的超重儿童与未超重儿童相比生存率更低。
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