基质金属蛋白酶-1、-3和-9基因多态性与中国汉族人群特发性扩张型心肌病的风险
Matrix metalloproteinase-1, -3, and -9 gene polymorphisms and the risk of idiopathic dilated cardiomyopathy in a Chinese Han population.
作者信息
Tang Li-Jiang, Chen Xiao-Feng, Zhu Min, Jiang Jian-Jun, Lu Xian-Ben, Du Yu-Xi, Wang Bin, Fang Chong-Feng, Xue Yin-Sheng, Shen Wei-Feng
机构信息
Department of Cardiology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang 317000, China.
出版信息
Clin Biochem. 2007 Dec;40(18):1427-30. doi: 10.1016/j.clinbiochem.2007.09.013. Epub 2007 Oct 3.
OBJECTIVES
To investigate the association between matrix metalloproteinase (MMP)-1(-1607 1G/2G), MMP-3(-1171 5A/6A), and MMP-9(-1562 C/T) polymorphism and susceptibility to idiopathic dilated cardiomyopathy (IDCM).
DESIGN AND METHODS
MMP-1, -3, -9 genotypes were determined by PCR-RFLP analysis.
RESULTS
Genotype frequency of MMP-3, but not MMP-1 and MMP-9 in IDCM patients, was significantly different from that in healthy controls.
CONCLUSIONS
Our data suggested that MMP-3 5A/6A polymorphism could be a risk factor for the susceptibility to IDCM.
目的
研究基质金属蛋白酶（MMP）-1（-1607 1G/2G）、MMP-3（-1171 5A/6A）和MMP-9（-1562 C/T）基因多态性与特发性扩张型心肌病（IDCM）易感性之间的关联。
设计与方法
采用聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）确定MMP-1、-3、-9基因型。
结果
IDCM患者中MMP-3的基因型频率与健康对照者有显著差异，而MMP-1和MMP-9无此差异。
结论
我们的数据表明，MMP-3 5A/6A基因多态性可能是IDCM易感性的一个危险因素。
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