Watanabe Kenatarou, Katou Toyofusa, Ikezawa Yasunori, Yajima Saki, Shionoya Hirohito, Akagi Takashi, Hamasaki Keita
Shibaura institute of technology, Department of applied chemistry, Toyosu 3-7-5, Koutou-ku, Tokyo 138-8548, Japan.
Nucleic Acids Symp Ser (Oxf). 2007(51):209-10. doi: 10.1093/nass/nrm105.
Twenty neamine derivatives having a nucleobase, adenine, cytosine, guanine or thimine with a lysine or an argine as a linker and, also, without linker were synthesized and their binding specificity for HIV TAR RNA was studied. Any nucleobase modification on neamine enhanced their binding affinities for TAR RNA. The binding affinity of neamine derivatives having a nucleobase at the closer position to neamine does not depend on the base, but having farther position has shown base specificity for TAR binding.
