Shibayama K, Nakamura T, Nagasato K, Shirabe S, Tsujihata M, Nagataki S
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
J Neurol Sci. 1991 Dec;106(2):186-92. doi: 10.1016/0022-510x(91)90256-7.
We treated 17 patients with HTLV-I-associated myelopathy (HAM) with interferon-alpha (IFN-alpha) in an open, nonrandomized, uncontrolled study. They were administered 1.5-9.0 x 10(6) international units of IFN-alpha daily for 4 weeks, and 4 patients showed a marked clinical response, 7 showed a moderate response and the others did not show any clinical response. Increased unstimulated (spontaneous) peripheral blood lymphocyte (PBL) proliferation was observed in all patients who were measured lymphocyte transformation. Spontaneous PBL proliferation was significantly inhibited by IFN-alpha treatment (P less than 0.01), whereas anti-HTLV-I-antibodies did not show any significant changes. Likewise, decreased stimulation indices to phytohemagglutinin (SI) due to increased spontaneous PBL proliferation were significantly increased after IFN-alpha treatment (P less than 0.01). In the patients who showed marked clinical responses, the changes of SI in IFN-alpha treatment were higher than those in other patients. These data indicate that further studies are warranted for evaluation of IFN-alpha treatment of HAM in a randomized, controlled study.
在一项开放性、非随机、无对照研究中，我们用α干扰素（IFN-α）治疗了17例人类嗜T淋巴细胞病毒I型相关脊髓病（HAM）患者。他们每天接受1.5 - 9.0×10⁶国际单位的IFN-α，持续4周，4例患者显示出明显的临床反应，7例显示出中度反应，其余患者未显示出任何临床反应。在所有检测淋巴细胞转化的患者中均观察到未刺激（自发）外周血淋巴细胞（PBL）增殖增加。IFN-α治疗可显著抑制自发PBL增殖（P<0.01），而抗HTLV-I抗体未显示出任何显著变化。同样，由于自发PBL增殖增加导致的对植物血凝素（SI）的刺激指数降低在IFN-α治疗后显著升高（P<0.01）。在显示出明显临床反应的患者中，IFN-α治疗期间SI的变化高于其他患者。这些数据表明，有必要在随机对照研究中进一步评估IFN-α治疗HAM的效果。
