Rossi L, Salvetti A, Batistoni R, Deri P, Gremigni V
Dipartimento di Morfologia Umana e Biologia Applicata, Sezione di Biologia e Genetica, Università di Pisa, Via Volta, 4, 56126, Pisa, Italy.
Cell Mol Life Sci. 2008 Jan;65(1):16-23. doi: 10.1007/s00018-007-7426-y.
Planarians possess amazing abilities to regulate tissue homeostasis and regenerate missing body parts. These features reside on the presence of a population of pluripotent/totipotent stem cells, the neoblasts, which are considered as the only planarian cells able to proliferate in the asexual strains. Neoblast distribution has been identified by mapping the cells incorporating bromodeoxyuridine, analyzing mitotic figures and using cell proliferation markers. Recently identified molecular markers specifically label subgroups of neoblasts, revealing thus the heterogeneity of the planarian stem cell population. Therefore, the apparent totipotency of neoblasts probably reflects the composite activities of multiple stem cell types. First steps have been undertaken to understand how neoblasts and differentiated cells communicate with each other to adapt the self-renewal and differentiation rates of neoblasts to the demands of the body. Moreover, the introduction of molecular resource database on planarians now paves the way to renewed strategies to understand planarian regeneration and stem cell-related issues.
涡虫具有调节组织内稳态和再生缺失身体部位的惊人能力。这些特性取决于一群多能/全能干细胞即新生细胞的存在，新生细胞被认为是无性繁殖品系中唯一能够增殖的涡虫细胞。通过绘制掺入溴脱氧尿苷的细胞图谱、分析有丝分裂图像以及使用细胞增殖标记物，已确定了新生细胞的分布。最近鉴定出的分子标记物可特异性标记新生细胞亚群，从而揭示了涡虫干细胞群体的异质性。因此，新生细胞明显的全能性可能反映了多种干细胞类型的综合活动。已经迈出了第一步来了解新生细胞与分化细胞如何相互沟通，以使新生细胞的自我更新和分化速率适应身体的需求。此外，关于涡虫的分子资源数据库的引入，现在为理解涡虫再生和干细胞相关问题的新策略铺平了道路。
