Pajalunga D, Mazzola A, Franchitto A, Puggioni E, Crescenzi M
Dept. of Environment and Primary Prevention, Istituto Superiore di Sanità - Viale Regina Elena, 299, 00161, Roma, Italy.
Cell Mol Life Sci. 2008 Jan;65(1):8-15. doi: 10.1007/s00018-007-7425-z.
Tissue repair and regeneration are very complex biological events, whose successful attainment requires far more than mere cell division. However, almost unavoidably they entail cell proliferation as a fundamental premise. Full regeneration or repair cannot be achieved without replacing cells lost to disease or injury, replacement that can only take place via proliferation of surviving cells. This review endeavors to outline the molecular bases of exit from and reentry into the cell cycle. In recent years, the decision to proliferate or not has been seen as mostly the concern of cyclins and cyclin-dependent kinases. This account tries to show that cell cycle inhibitors are as important as the positive regulators in the making of this decision. Finally, the authors wish to suggest that the molecular knowledge of the cell cycle can be harnessed to the benefit of many aspects of regenerative medicine.
组织修复和再生是非常复杂的生物学过程，其成功实现所需的远不止单纯的细胞分裂。然而，几乎不可避免地，它们需要细胞增殖作为基本前提。如果不替换因疾病或损伤而损失的细胞，就无法实现完全再生或修复，而这种替换只能通过存活细胞的增殖来进行。本综述旨在概述细胞周期退出和重新进入的分子基础。近年来，细胞是否增殖的决定主要被视为细胞周期蛋白和细胞周期蛋白依赖性激酶的问题。本文试图表明，在做出这一决定时，细胞周期抑制剂与正向调节因子同样重要。最后，作者希望指出，细胞周期的分子知识可用于再生医学的诸多方面，使其受益。
