Suzuki T, Otani K, Misawa M
Department of Applied Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Jpn J Pharmacol. 1991 Dec;57(4):455-62. doi: 10.1254/jjp.57.455.
The purpose of this experiment is to investigate genetic differences in the development of physical dependence on morphine and codeine in inbred strains of mice, C57BL/6, C3H/He and DBA/2. Mice were treated with morphine- or codeine-admixed food (1, 2 and 3 mg/g of food) for 3 to 9 days. After the termination of drug treatment, the mice were given naloxone (5 mg/kg, s.c.). The incidences of jumping and teeth chattering by naloxone challenge in morphine- and codeine-treated C57BL/6 mice were much greater than those in C3H/He and DBA/2 mice. However, the incidences of other naloxone-precipitated withdrawal signs, such as ptosis and diarrhea, were not different among the three inbred strains of mice. These results indicate that genotype is an important determinant of the degree of most naloxone-precipitated withdrawal signs in morphine- and codeine-treated mice.
本实验的目的是研究C57BL/6、C3H/He和DBA/2近交系小鼠对吗啡和可待因产生身体依赖性过程中的遗传差异。小鼠用含吗啡或可待因的食物（1、2和3毫克/克食物）处理3至9天。药物治疗结束后，给小鼠皮下注射纳洛酮（5毫克/千克）。在接受吗啡和可待因处理的C57BL/6小鼠中，纳洛酮激发引起的跳跃和牙齿打颤发生率远高于C3H/He和DBA/2小鼠。然而，其他纳洛酮诱发的戒断症状，如眼睑下垂和腹泻，在这三种近交系小鼠中并无差异。这些结果表明，基因型是决定吗啡和可待因处理小鼠中大多数纳洛酮诱发戒断症状程度的重要因素。
