Solov'eva O E, Konovalov P V, Vikulova N A, Katsnel'son L B, Markhasin V S
Ross Fiziol Zh Im I M Sechenova. 2007 Sep;93(9):945-68.
Mathematical models have been developed to describe interactions of electrical, mechanical and chemical processes in cardiomyocytes. The models simulate wide range of experimental data on excitation-contraction coupling and, more importantly, on mechanoelectric feedback in heart muscle. The model results clearly show that mechano-dependence of intracellular calcium handling due to cooperative effects of contractile proteins activation plays a key role in cardiac mechanoelectric coupling. At the same time, mechanosensitive currents can also contribute to action potential responses to mechanical perturbations. Using this model to study the heterogeneous myocardium we have shown that temporal and functional electromechanical heterogeneity of coupled cardiomyocytes can essentially determine the myocardium contractility. Optimization of the electromechanical function of contractile system emerges from the fine coordination between the activation sequence of cardiomyocytes, their local electromechanical properties and the mechanical interaction during contraction.
已经开发出数学模型来描述心肌细胞中电、机械和化学过程的相互作用。这些模型模拟了关于兴奋-收缩偶联，更重要的是关于心肌机械电反馈的大量实验数据。模型结果清楚地表明，由于收缩蛋白激活的协同作用，细胞内钙处理的机械依赖性在心脏机械电偶联中起关键作用。同时，机械敏感电流也可有助于动作电位对机械扰动的反应。利用该模型研究异质性心肌，我们已经表明，耦合心肌细胞的时间和功能机电异质性可从根本上决定心肌收缩性。收缩系统机电功能的优化源于心肌细胞激活序列、其局部机电特性以及收缩过程中的机械相互作用之间的精细协调。
