Krieg Arthur M
Coley Pharmaceutical Group, 93 Worcester Street, Suite 101, Wellesley, MA 02481, USA.
Immunity. 2007 Nov;27(5):695-7. doi: 10.1016/j.immuni.2007.11.001.
Toll-like receptor 7 (TLR7) detects viral RNA, but can be activated inappropriately by self-RNA, leading to autoimmunity. Deane et al. (2007) show that Tlr7 gene dosage is directly related to the risk of lupus in a mouse model.
Toll样受体7（TLR7）可检测病毒RNA，但也可能被自身RNA异常激活，从而导致自身免疫。迪恩等人（2007年）表明，在小鼠模型中，Tlr7基因剂量与患狼疮的风险直接相关。
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