Yanagawa Youichi, Nishi Kouichirou, Tomiharu Niida, Kawaguchi Takeo
Int J Cardiol. 2009 Feb 20;132(2):e65-7. doi: 10.1016/j.ijcard.2007.08.022. Epub 2007 Nov 26.
A sixty-five-year old female, with a past history of variant angina and asthma, collapsed after complaining of chest pain and regained spontaneous circulation by resuscitation. An electrocardiograph showed a QS pattern on the precordial leads and sonography revealed a takotsubo cardiomyopathy-like movement. During induced hypothermic therapy for protection of her brain and heart using a drug which dilated the coronary artery, she collapsed again with ventricular flatter for 40 min; however, she re-obtained return of spontaneous circulation and eventually regained consciousness. After correction of eosinophilia by steroids, the variant angina with life-threatening arrhythmia and asthma attack subsided. She was discharged and ambulatory 14 days after admission with normal motion of the cardiac wall. This is the first case of Kounis syndrome associated with takotsubo cardiomyopathy. The mechanism of the concurrent condition of this case is herein discussed.
一名65岁女性，既往有变异型心绞痛和哮喘病史，在主诉胸痛后晕倒，经复苏恢复自主循环。心电图显示胸前导联呈QS型，超声心动图显示类似Takotsubo心肌病的运动。在使用一种扩张冠状动脉的药物进行诱导低温治疗以保护其脑和心脏期间，她再次晕倒，室性逸搏40分钟；然而，她再次恢复自主循环并最终苏醒。在使用类固醇纠正嗜酸性粒细胞增多后，伴有危及生命心律失常的变异型心绞痛和哮喘发作缓解。她在入院14天后出院，心脏壁运动正常，可自由活动。这是首例与Takotsubo心肌病相关的Kounis综合征病例。本文讨论了该病例并发情况的机制。
