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本文引用的文献

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Resistance to insulin in mentally disturbed soldiers.精神障碍士兵对胰岛素的抵抗
Arch Neurol Psychiatry. 1946 Jul;56(1):74-8. doi: 10.1001/archneurpsyc.1946.02300180084007.
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Neurological soft signs and minor physical anomalies in patients with schizophrenia and related disorders, their first-degree biological relatives, and non-psychiatric controls.精神分裂症及相关障碍患者、其一级生物学亲属和非精神科对照者的神经软体征和轻微身体异常。
Schizophr Res. 2007 Aug;94(1-3):64-73. doi: 10.1016/j.schres.2007.04.002. Epub 2007 May 23.
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Impaired glucose tolerance in first-episode drug-naïve patients with schizophrenia.首发未用药精神分裂症患者的糖耐量受损
Diabet Med. 2007 May;24(5):481-5. doi: 10.1111/j.1464-5491.2007.02092.x. Epub 2007 Mar 22.
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Family and case-control association study of the tumor necrosis factor-alpha (TNF-alpha) gene with schizophrenia and response to antipsychotic medication.肿瘤坏死因子-α（TNF-α）基因与精神分裂症及抗精神病药物反应的家系及病例对照关联研究。
Psychopharmacology (Berl). 2006 Oct;188(2):171-82. doi: 10.1007/s00213-006-0482-4. Epub 2006 Aug 24.
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[Incidence of type 2 diabetes and its diagnosis process in the decade 1991-2000 in a primary health care centre].
Gac Sanit. 2006 Mar-Apr;20(2):124-31. doi: 10.1157/13087323.
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Neural anomalies during sustained attention in first-degree biological relatives of schizophrenia patients.精神分裂症患者一级血亲在持续注意力过程中的神经异常。
Biol Psychiatry. 2006 Aug 1;60(3):242-52. doi: 10.1016/j.biopsych.2005.11.017. Epub 2006 Feb 7.
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Clustering of metabolic comorbidity in schizophrenia: a genetic contribution?精神分裂症中代谢合并症的聚类：遗传因素的作用？
J Psychopharmacol. 2005 Nov;19(6 Suppl):47-55. doi: 10.1177/0269881105058380.
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Prepulse facilitation and prepulse inhibition in schizophrenia patients and their unaffected siblings.精神分裂症患者及其未患病同胞的预脉冲易化和预脉冲抑制
Biol Psychiatry. 2004 Mar 1;55(5):518-23. doi: 10.1016/j.biopsych.2003.10.018.
9
Functional magnetic resonance imaging during auditory verbal working memory in nonpsychotic relatives of persons with schizophrenia: a pilot study.精神分裂症患者非精神病性亲属听觉言语工作记忆期间的功能磁共振成像：一项初步研究。
Biol Psychiatry. 2004 Mar 1;55(5):490-500. doi: 10.1016/j.biopsych.2003.11.014.
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Neurological and morphological anomalies and the genetic liability to schizophrenia: a composite phenotype.神经和形态学异常以及精神分裂症的遗传易感性：一种复合表型。
Schizophr Res. 2004 Mar 1;67(1):23-31. doi: 10.1016/s0920-9964(03)00099-9.

非情感性精神病患者的2型糖尿病家族史。

Parental history of type 2 diabetes in patients with nonaffective psychosis.

作者信息

Fernandez-Egea Emilio, Miller Brian, Bernardo Miguel, Donner Thomas, Kirkpatrick Brian

机构信息

Programa Esquizofrenia Clinic, Servel de Psiquiatria, Institut de Neurociencies, Hospital Clinic, Department de Psiquiatria, Universitat de Barcelona, Barcelona, Spain.

出版信息

Schizophr Res. 2008 Jan;98(1-3):302-6. doi: 10.1016/j.schres.2007.10.002. Epub 2007 Nov 26.

DOI:10.1016/j.schres.2007.10.002
PMID:18031995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2703822/
Abstract

INTRODUCTION

We attempted to replicate two previous studies which found an increased risk of diabetes in the relatives of schizophrenia probands.

METHODS

N=34 patients with newly-diagnosed nonaffective psychosis and N=52 non-psychiatric controls were interviewed for parental history of Type 2 diabetes.

RESULTS

In a logistic regression model that included multiple potential confounders, psychosis was a significant predictor of Type 2 diabetes in either parent (p<0.04).

DISCUSSION

We found an increased prevalence of Type 2 diabetes in the parents of nonaffective psychosis subjects. This association may be due to shared environmental or genetic risk factors, or both.

摘要

引言

我们试图重复之前的两项研究，这两项研究发现精神分裂症先证者的亲属患糖尿病的风险增加。

方法

对34例新诊断的非情感性精神病患者和52例非精神病对照者进行访谈，了解其父母2型糖尿病病史。

结果

在一个包含多个潜在混杂因素的逻辑回归模型中，精神病是父母任何一方患2型糖尿病的显著预测因素（p<0.04）。

讨论

我们发现非情感性精神病患者的父母中2型糖尿病的患病率增加。这种关联可能是由于共同的环境或遗传风险因素，或两者兼而有之。