Giegé P, Grienenberger J M, Bonnard G
Institut de Biologie Moléculaire des Plantes du CNRS, Université Louis Pasteur, 12 rue du général Zimmer, 67084 Strasbourg, France.
Mitochondrion. 2008 Jan;8(1):61-73. doi: 10.1016/j.mito.2007.10.001. Epub 2007 Oct 11.
As part of the respiratory chain, c-type cytochromes are essential electron transporters. They are characterized by the covalent attachment of a heme prosthetic group. The biogenesis of these proteins includes all the processes leading to this fixation. Yeast and animals have evolved a comparatively simple mechanism relying on cytochrome c heme lyases. In contrast, plant mitochondria have kept a maturation pathway inherited from their prokaryote ancestor. It involves Ccm proteins encoded in both the nuclear and the mitochondrial genomes of plants. These proteins compose a heme delivery pathway, include an ABC transporter, a redox protein and a putative heme lyase.
作为呼吸链的一部分，c型细胞色素是必不可少的电子转运体。它们的特征是共价连接一个血红素辅基。这些蛋白质的生物合成包括导致这种固定的所有过程。酵母和动物进化出了一种相对简单的机制，依赖于细胞色素c血红素裂合酶。相比之下，植物线粒体保留了从其原核祖先遗传下来的成熟途径。它涉及植物核基因组和线粒体基因组中编码的Ccm蛋白。这些蛋白质构成了一条血红素传递途径，包括一个ABC转运蛋白、一个氧化还原蛋白和一个假定的血红素裂合酶。
